Pathogen Inactivation: Prospects and Pitfalls
ثبت نشده
چکیده
Submit Manuscript | http://medcraveonline.com have proven to be effective against numerous bacteria, viruses, and parasites. Two main systems have emerged to treat platelet concentrates: treatment with psoralen ultraviolet A (UVA) light and treatment with riboflavin (vitamin B2) plus ultraviolet B (UVB) light, both targeting the nucleic acids of pathogens. The ability of the Mirasol PRT system to inactivate both pathogens and white blood cells has been previously described.1The technology uses a combination of riboflavin and UV light to induce irreversible lesions in the nucleic acids of pathogens and white blood cells (WBCs) to inhibit replication and function [2].
منابع مشابه
Immunogenicity of commercial, formaldehyde and binary ethylenimine inactivated Newcastle disease virus vaccines in specific pathogen free chickens
Newcastle disease (ND) is one of the most important diseases that affect birds; the epizootic nature of the disease has caused severe economic losses in the poultry industry worldwide. In this experiment ND virus (NDV) was inactivated by two different chemicals binary ethylenimine (BEI) and formaldehyde. Formaldehyde was used at 0.1%, while BEI was used at concentrations of 1 to 4 mM. NDV inact...
متن کاملThe Effect of Methylene Blue in Combination with Red Visible Light on Model Viruses Inactivation and Coagulation Factors in Fresh Frozen Plasma
Background and Aims: Fresh Frozen Plasma (FFP) is one of blood components. The risk of transmission of viruses from blood components regardless selection of blood donors and screening donated blood still remains. There are several methods for viral inactivation. In this study methylene blue (MB) photo inactivation process was used for inactivating viruses. Materials and Methods: In this study M...
متن کاملInduction of Nucleic Acid Damage in Viral Genomes Using Riboflavin in Combination with UV Light
Background and Aims: Despite the screening of blood donors, blood transfusion represents an ideal port of entry for blood-borne infection. Blood-borne pathogen transmission has been a concern since the earliest days of transfusion. The blood product of platelet (PLT) concentrates is still faced with the risk of bacterial and viral contaminations. Pathogen inactivation technologies offer a proac...
متن کاملInduction of Nucleic Acid Damage in Viral Genomes using Riboflavin in Combination with UV Light
Background and Aims: Despite the screening of blood donors, blood transfusion represents an ideal port of entry for blood-borne infection. Blood-borne pathogen transmission has been a concern since the earliest days of transfusion. The blood product of platelet (PLT) concentrates is still faced with the risk of bacterial and viral contaminations. Pathogen inactivation technologies offer a proac...
متن کامل